Protein phase separation in mitosis

Abstract

Through phase separation, some proteins form liquid-like condensates or droplets which can flow, fuse, and even deform when pressure is applied. In some cases, the condensates 'mature' to form gel or solid-like structure. Recent studies suggest that the liquid-like condensates form the structural basis for several membrane-less subcellular organelles such as stress granules and other subcellular structures. Here, we review and discuss studies that implicate protein phase separation in the function of the spindle apparatus and centrosomes.