General anesthesia vs local anesthesia during mechanical thrombectomy in acute ischemic stroke

J Neurol Sci. 2019 Aug 15:403:13-18. doi: 10.1016/j.jns.2019.05.034. Epub 2019 May 30.


Objective: To investigate the effect of general anesthesia (GA) on functional outcomes and complications rates in acute ischemic stroke (AIS) patients treated with mechanical thrombectomy (MT) compared to the use of local anesthesia (LA) at the puncture site.

Methods: This observational study was based on a prospectively registry study. AIS patients underwent MT with GA or LA from January 2013 to October 2017 were included. The primary outcome was the modified Rankin Scale (mRS) score at 90 days post-intervention. Furthermore, we assessed the long-term outcome of these patients. Multivariable logistic regression analysis was conducted to adjust for confounders.

Results: We enrolled 187 AIS patients in this study, patients in GA group had a similar mRS score compared to LA group at 90 days (2 [IQR, 1-4] vs 2.5 [IQR, 1-4], P = .917). No differences were found in the rates of functional independence (mRS 0-2), no or minimal disability (mRS 0-1), and mortality (mRS 6) between the 2 groups at 90 days post-intervention as well as long-term follow-up. The procedure-related complications and serious adverse events were similar between the LA group and GA group (P > .05 each). In multivariable analysis, GA use was not associated with functional outcomes.

Conclusion: AIS patients who received GA during MT had similar functional outcomes and complications rates compared to patients received LA.

Keywords: Anesthesia; Mechanical thrombectomy; Outcome; Stroke.

Publication types

  • Comparative Study
  • Observational Study

MeSH terms

  • Anesthesia, General / adverse effects*
  • Anesthesia, Local / adverse effects*
  • Brain Ischemia / complications*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Recovery of Function / drug effects*
  • Stroke / complications*
  • Thrombectomy / methods*