Prevalence of vitamin D deficiency and its association with metabolic derangements among children with obesity

BMC Pediatr. 2019 Jun 8;19(1):186. doi: 10.1186/s12887-019-1558-8.


Background: It is known that obesity is associated with vitamin D deficiency and observational studies have shown vitamin D deficiency to be linked with the development of type 2 diabetes. There are no comprehensive data regarding vitamin D deficiency in children with obesity in Sri Lanka and the objective of the study was to assess the prevalence of Vitamin D deficiency and its association with metabolic derangements among children with obesity.

Methodology: Two hundred and two children between 5 and 15 years of age attending the obesity clinic Lady Ridgeway Hospital (LRH) were recruited excluding those having possible secondary causes for obesity. Blood was drawn after 12-h overnight fast for fasting blood glucose(FBG), lipid profile, serum insulin, alanine aminotransferase (ALT),aspartate aminotransferase(AST), Vitamin D, parathyroid hormone(PTH),high sensitivity C reactive protein(hs-CRP). Oral glucose tolerance test (OGTT) was done with 2 h random blood glucose. Anthropometry, blood pressure were measured, and body fat mass was assessed using bio-impedance.

Results: Vitamin D deficiency (< 20 ng/ml) was seen in 152(75.2%) children and 43(21.3%) had insufficient (20-30 ng/ml) levels. Skin fold thickness, fasting and post-glucose insulin, HOMA-IR, PTH, LDL, Serum cholesterol and hs-CRP showed statistically significant negative correlations with Vitamin D levels.

Conclusions: Vitamin D deficiency was significantly high in Sri Lankan children with obesity and showed significant negative correlations with indicators of insulin resistance and adiposity.

Keywords: Childhood obesity; Sri Lankan children; Vitamin D deficiency.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adiposity
  • Adolescent
  • Blood Glucose / analysis
  • Child
  • Child, Preschool
  • Cholesterol / blood
  • Cross-Sectional Studies
  • Female
  • Glucose Tolerance Test
  • Humans
  • Insulin / blood
  • Insulin Resistance
  • Intra-Abdominal Fat / diagnostic imaging
  • Lipoproteins, HDL / blood
  • Liver / diagnostic imaging
  • Male
  • Pediatric Obesity / blood
  • Pediatric Obesity / complications
  • Pediatric Obesity / epidemiology*
  • Prevalence
  • Sri Lanka / epidemiology
  • Triglycerides / blood
  • Vitamin D / blood
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / complications
  • Vitamin D Deficiency / epidemiology*


  • Blood Glucose
  • Insulin
  • Lipoproteins, HDL
  • Triglycerides
  • Vitamin D
  • Cholesterol