Blood biomarkers to predict short-term pulmonary exacerbation risk in children and adolescents with CF: A pilot study

J Cyst Fibros. 2020 Jan;19(1):49-51. doi: 10.1016/j.jcf.2019.05.020. Epub 2019 Jun 5.


In CF, pulmonary exacerbations (PEx) can lead to permanent loss in lung function and thus should be prevented. Previously, we identified a blood protein biosignature consisting of 6 proteins capable of predicting short-term PEx events in CF adults. In this study, we utilized blood samples from the placebo arm of a randomized controlled trial to assess whether this candidate protein biosignature was also capable of predicting short-term PEx events in CF children and adolescents. This pilot study provides preliminary evidence that blood inflammation can be monitored to predict short-term PEx risk in CF children and adolescents.

Keywords: Biomarkers; Proteomics; Pulmonary exacerbations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Biomarkers / blood*
  • Child
  • Cystic Fibrosis / blood*
  • Cystic Fibrosis / microbiology
  • Cystic Fibrosis / physiopathology
  • Cystic Fibrosis / therapy
  • Disease Progression
  • Female
  • Humans
  • Male
  • Pilot Projects
  • Predictive Value of Tests
  • Prognosis
  • Proteomics / methods*
  • Respiratory Function Tests / methods
  • Respiratory Tract Infections* / diagnosis
  • Respiratory Tract Infections* / etiology
  • Respiratory Tract Infections* / microbiology
  • Respiratory Tract Infections* / prevention & control


  • Biomarkers