Adjuvant drug-assisted bone healing: Part III - Further strategies for local and systemic modulation

Clin Hemorheol Microcirc. 2019;73(3):439-488. doi: 10.3233/CH-199104.


In this third in a series of reviews on adjuvant drug-assisted bone healing, further approaches aiming at influencing the healing process are discussed. Local and systemic modulation of bone metabolism is pursued with use of a number of drugs with completely different indications, which are characterized by a pleiotropic spectrum of action. These include drugs used to treat lipid disorders (HMG-CoA reductase inhibitors), hypertension (ACE inhibitors), osteoporosis (bisphosphonates), cancer (proteasome inhibitors) and others. Potential applications to enhance bone healing are discussed.

Keywords: Bisphosphonates; Wnt signaling; bone metabolism; critical-size bone defects; small molecules; statins; strontium.

MeSH terms

  • Adjuvants, Pharmaceutic / pharmacology
  • Adjuvants, Pharmaceutic / therapeutic use*
  • Bone Regeneration / drug effects*
  • Humans


  • Adjuvants, Pharmaceutic