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Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium

Xiang-Zhen Kong  1 Premika S W Boedhoe  2 Yoshinari Abe  3 Pino Alonso  4 Stephanie H Ameis  5 Paul D Arnold  6 Francesca Assogna  7 Justin T Baker  8 Marcelo C Batistuzzo  9 Francesco Benedetti  10 Jan C Beucke  11 Irene Bollettini  10 Anushree Bose  12 Silvia Brem  13 Brian P Brennan  8 Jan Buitelaar  14 Rosa Calvo  15 Yuqi Cheng  16 Kang Ik K Cho  17 Sara Dallaspezia  10 Damiaan Denys  18 Benjamin A Ely  19 Jamie Feusner  20 Kate D Fitzgerald  21 Jean-Paul Fouche  22 Egill A Fridgeirsson  23 David C Glahn  24 Patricia Gruner  25 Deniz A Gürsel  26 Tobias U Hauser  27 Yoshiyuki Hirano  28 Marcelo Q Hoexter  9 Hao Hu  29 Chaim Huyser  30 Anthony James  31 Fern Jaspers-Fayer  32 Norbert Kathmann  11 Christian Kaufmann  11 Kathrin Koch  26 Masaru Kuno  28 Gerd Kvale  33 Jun Soo Kwon  34 Luisa Lazaro  35 Yanni Liu  21 Christine Lochner  36 Paulo Marques  37 Rachel Marsh  38 Ignacio Martínez-Zalacaín  39 David Mataix-Cols  40 Sarah E Medland  41 José M Menchón  4 Luciano Minuzzi  42 Pedro S Moreira  37 Astrid Morer  35 Pedro Morgado  37 Akiko Nakagawa  28 Takashi Nakamae  3 Tomohiro Nakao  43 Janardhanan C Narayanaswamy  12 Erika L Nurmi  20 Joseph O'Neill  20 Jose C Pariente  44 Chris Perriello  45 John Piacentini  20 Fabrizio Piras  7 Federica Piras  7 Christopher Pittenger  25 Y C Janardhan Reddy  12 Oana Georgiana Rus-Oswald  46 Yuki Sakai  47 Joao R Sato  48 Lianne Schmaal  49 H Blair Simpson  50 Noam Soreni  51 Carles Soriano-Mas  52 Gianfranco Spalletta  53 Emily R Stern  54 Michael C Stevens  55 S Evelyn Stewart  56 Philip R Szeszko  57 David F Tolin  58 Aki Tsuchiyagaito  59 Daan van Rooij  14 Guido A van Wingen  23 Ganesan Venkatasubramanian  12 Zhen Wang  60 Je-Yeon Yun  61 ENIGMA OCD Working GroupPaul M Thompson  62 Dan J Stein  63 Odile A van den Heuvel  2 Clyde Francks  64
Collaborators, Affiliations

Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium

Xiang-Zhen Kong et al. Biol Psychiatry.

Abstract

Background: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD.

Methods: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status.

Results: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = -0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets.

Conclusions: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.

Keywords: Brain asymmetry; Laterality; Mega-analysis; Obsessive-compulsive disorder; Pallidum; Thalamus.

Conflict of interest statement

Disclosures

The authors declare no conflicts of interest except for the authors below:

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