Background and purpose: Since the first case of fecal microbiota transplantation for the treatment of ulcerative colitis was described in the year 1989, there have been an increment of case reports, case series, cohort studies, and randomized controlled trials (RCTs). In this study, we were going to investigate general clinical remission, clinical response, and steroid-free remission of fecal microbiota transplantation.
Methods: We searched Ovid Medline, Ovid EMBASE, and Cochrane Library, focusing prospective studies including randomized controlled trials and cohort studies. The outcomes were clinical remission, clinical response, steroid-free remission, and serious adverse events. We used RevMan 5.3 software for meta-analyses.
Key results: A total of 4 RCTs and 2 cohort studies (340 cases from 5 countries) were included. We found that FMT might be more effective than placebo on clinical remission (OR, 3.85 [2.21, 6.7]; P < 0.001; I 2 = 0%) and clinical response (OR, 2.75 [1.33, 5.67]; P = 0.006; I 2 = 49%), but no statistical difference on steroid-free remission (OR, 2.08 [0.41, 10.5]; P = 0.37; I 2 = 69%) and serious adverse events (OR, 2.0 [0.17, 22.97]; P = 0.44; I 2 = 0%).
Conclusions and inferences: Fecal microbiota transplantations were associated with significant clinical remission and response in ulcerative colitis patients while there was no significant difference found between FMT and placebo in steroid-free remission. Moreover, a common consensus on the route, volume, timing, preferred donor characteristics, and frequency of fecal administration is necessary to achieve remission.
Systematic Review With Meta-Analysis: Faecal Microbiota Transplantation for the Induction of Remission for Active Ulcerative ColitisSP Costello et al. Aliment Pharmacol Ther 46 (3), 213-224. PMID 28612983. - ReviewDespite variation in processes, FMT appears to be effective for induction of remission in UC, with no major short-term safety signals. Further studies are needed to bette …
[Fecal Microbiota Transplantation for the Treatment of Ulcerative Colitis: A Meta-analysis]R Mo et al. Zhonghua Nei Ke Za Zhi 58 (3), 202-208. PMID 30803179. - Meta-Analysis目的： 采用Meta分析方法系统评价粪微生态移植（FMT）治疗溃疡性结肠炎（UC）的疗效和安全性。 方法： 在PubMed、Cochrane Library、Embase、中国知网（CNKI）、维普、万方数据库检索关于FMT治疗UC的临床研究，检索时限为从建库到2018年5月。由2名评价者按纳入与排除标准进行文 …
Efficacy of Fecal Microbiota Therapy in Steroid Dependent Ulcerative Colitis: A Real World Intention-To-Treat AnalysisA Sood et al. Intest Res 17 (1), 78-86. PMID 30449078.A multisession FMT via the colonoscopic route is a promising therapeutic option for patients with steroid-dependent UC, as it can induce clinical remission and aid in ste …
Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled TrialP Moayyedi et al. Gastroenterology 149 (1), 102-109.e6. PMID 25857665. - Randomized Controlled TrialFMT induces remission in a significantly greater percentage of patients with active UC than placebo, with no difference in adverse events. Fecal donor and time of UC appe …
Etrolizumab for Induction of Remission in Ulcerative ColitisG Rosenfeld et al. Cochrane Database Syst Rev (12), CD011661. PMID 26630451. - ReviewModerate quality evidence suggests that etrolizumab may be an effective induction therapy for some patients with moderate to severe ulcerative colitis who have failed con …
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Recent Advances in Modulating the MicrobiomeEMM Quigley et al. F1000Res 9. PMID 32047611. - ReviewWe are in the midst of "the microbiome revolution"-not a day goes by without some new revelation on the potential role of the gut microbiome in some disease or disorder. …