Growth and metabolism of mannitol by strains of Saccharomyces cerevisiae

J Gen Microbiol. 1987 Jul;133(7):1675-84. doi: 10.1099/00221287-133-7-1675.


Of 40 polyploid strains of Saccharomyces cerevisiae screened for growth on D-mannitol (5%, w/v), half grew well (5-20 mg dry biomass ml-1). Certain of these strains were unable to grow on low concentrations of mannitol (1-2%, w/v) and others, initially unable to grow on mannitol, exhibited long-term adaptation to growth. An NAD+-dependent D-mannitol dehydrogenase (EC was detected in mannitol-grown yeast. Growth was dependent on mitochondrial function and was obligately aerobic. Measurement of products of metabolism and respiratory activity indicated that growth on mannitol allows catabolite derepression.

MeSH terms

  • Anaerobiosis
  • Culture Media
  • Mannitol / metabolism*
  • Oxygen Consumption
  • Saccharomyces cerevisiae / growth & development*
  • Sorbitol / metabolism


  • Culture Media
  • Mannitol
  • Sorbitol