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. 2019 Aug:112:233-239.
doi: 10.1016/j.molimm.2019.05.014. Epub 2019 Jun 7.

Decreased number of CD19+CD24hiCD38hi regulatory B cells in Diabetic nephropathy

Tao Li  1 , Zhenxiang Yu  2 , Zhihui Qu  3 , Nan Zhang  4 , Rebecca Crew  5 , Yanfang Jiang  6
Affiliations

Decreased number of CD19+CD24hiCD38hi regulatory B cells in Diabetic nephropathy

Tao Li et al. Mol Immunol. 2019 Aug.

Abstract

Regulatory B cells participate in the pathogenesis of autoimmune disease. This study aimed to examine the putative contribution of regulatory B cells to the pathogenesis of DN. The number of circulating CD19+CD24hiCD38hi B cells, CD19+CD24hiCD38hiCD5+ B cells, and CD19+CD24hiCD38hiIL-10+ B cells were significantly lower in DN patients (p < 0.05) than the control group. The number of circulating CD19+CD24hiCD38hi B cells was positively correlated with the levels of eGFR and serum IL-10 levels, but negatively correlated with urinary protein levels in DN patients. Treatment significantly increased the number of CD19+CD24hiCD38hi B cells, CD19+CD24hiCD38hiCD5+ B cells, CD19+CD24hiCD38hiIL-10+ B cells, and the levels of serum IL-10 (p < 0.05). We conclude that regulatory B cells may present new targets for intervention of DN.

Keywords: Diabetic nephropathy; IL-10; Regulatory B cells; Urinary protein; eGFR.

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