Vascular endothelial growth factor gene polymorphisms in patients with rosacea: A case-control study

J Am Acad Dermatol. 2019 Aug;81(2):348-354. doi: 10.1016/j.jaad.2019.03.055. Epub 2019 Jun 8.


Background: Rosacea is a chronic disease that is characterized by facial skin inflammation and vascular abnormality. Vascular endothelial growth factor (VEGF) is a potent mediator of vascular permeability and inflammation that might play a role in the pathogenesis of rosacea.

Objective: This study aimed to determine the association between VEGF gene polymorphisms and rosacea.

Methods: A case-control study design was used to compare 100 patients with rosacea and 100 age- and gender-matched control subjects in terms of VEGF polymorphisms based on polymerase chain reaction and the serum level of VEGF and VEGF receptors based on enzyme-linked immunosorbent assay.

Results: Heterozygous and homozygous +405C/G polymorphism of the VEGF gene was observed to increase the risk of rosacea 1.7-fold (95% confidence interval 1.2-4.2) and 2.3-fold (95% confidence interval 1.2-4.2), respectively. There was a significant positive correlation between the severity of rosacea and +405C/G polymorphism of the VEGF gene in patients with erythematotelangiectatic rosacea.

Limitations: Serum VEGF and VEGF receptor levels were measured in the limited number of patients.

Conclusion: The present findings indicate that +405C/G polymorphism of the VEGF gene increases the risk of rosacea.

Keywords: VEGF gene polymorphism; rosacea; vascular endothelial growth factor.

MeSH terms

  • Adult
  • Case-Control Studies
  • Female
  • Heterozygote
  • Homozygote
  • Humans
  • Male
  • Middle Aged
  • Patient Acuity
  • Polymorphism, Genetic
  • Receptors, Vascular Endothelial Growth Factor / blood
  • Risk Factors
  • Rosacea / blood*
  • Rosacea / genetics*
  • Vascular Endothelial Growth Factor A / blood*
  • Vascular Endothelial Growth Factor A / genetics*


  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • Receptors, Vascular Endothelial Growth Factor