[An Overlap between Splicing Sites in RNA and Homo-Repeats in Human Proteins]

Mol Biol (Mosk). May-Jun 2019;53(3):524-528. doi: 10.1134/S0026898419030066.
[Article in Russian]

Abstract

Proteins with homo-repeats of more than 4 amino acid residues in length were examined to understand whether some splicing sites in pre-mRNA may be attributed to homo-repeats in human proteins. The human proteome was found to contain a total of 404 proteins with homo-repeats that account for at least one splicing site in pre-mRNA. Pre-mRNA splicing sites were more often found in the C-terminal part (67%) than in the middle orN-terminal part of a homo-repeat. Ten homo-repeats were identified to have two splicing sites per repeat. The repeats were lysine homo-repeats in all but one case.

Keywords: disease; disordered regions; homo-repeat; splicing.

MeSH terms

  • Humans
  • Lysine / genetics
  • Lysine / metabolism
  • Proteins / analysis*
  • Proteins / chemistry*
  • Proteins / genetics
  • Proteome / analysis
  • Proteome / chemistry
  • Proteome / genetics
  • RNA Precursors / genetics*
  • RNA Splice Sites / genetics*
  • RNA Splicing / genetics
  • Repetitive Sequences, Amino Acid / genetics*

Substances

  • Proteins
  • Proteome
  • RNA Precursors
  • RNA Splice Sites
  • Lysine