Lack of an Association between a Polymorphism in the KRAS 3' Untranslated Region (rs61764370) and Endometriosis in a Large European Case-Control Study

Gynecol Obstet Invest. 2019;84(6):575-582. doi: 10.1159/000500626. Epub 2019 Jun 11.


Background: Endometriosis is a common disorder that affects 6-10% of reproductive age women. In a previous study, we demonstrated that a polymorphism in let-7 microRNA-binding site in the 3' untranslated region of the KRAS gene was found in 31% of subjects with endometriosis resistant to medical therapy. This polymorphism was now tested in a large, case-control study.

Methods: Peripheral blood or peritoneal biopsies from 2,077 European subjects with or without endometriosis and known infertility were tested for the presence of the variant allele using polymerase chain reaction.

Results: Histologically proven endometriosis was found in 1,140 subjects, while 937 subjects were disease free. Variant allele carrier rates in subjects with and without endometriosis were 15.7 and 15.1%, respectively. No association between the variant KRAS allele and stage of the disease, age at surgery, body mass index, or type of infertility was identified.

Conclusion: A germ-line single-nucleotide polymorphism in the let-7 microRNA-binding site of the KRAS gene was not associated with sporadic endometriosis in an infertile Caucasian population in this large case-control study. However, it remains possible that this gene variant may be a marker of treatment resistance. Further studies on the role of this polymorphism in endometriosis are needed.

Keywords: Endometriosis; KRAS; Single-nucleotide polymorphism.

MeSH terms

  • 3' Untranslated Regions / genetics*
  • Adult
  • Binding Sites / genetics
  • Case-Control Studies
  • Endometriosis / genetics*
  • Europe
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Infertility, Female / etiology
  • MicroRNAs / genetics
  • Polymorphism, Single Nucleotide / genetics*
  • Proto-Oncogene Proteins p21(ras) / genetics*
  • White People


  • 3' Untranslated Regions
  • KRAS protein, human
  • MicroRNAs
  • mirnlet7 microRNA, human
  • Proto-Oncogene Proteins p21(ras)