Some naturally occurring compounds that increase longevity and stress resistance in model organisms of aging

Biogerontology. 2019 Oct;20(5):583-603. doi: 10.1007/s10522-019-09817-2. Epub 2019 Jun 11.


Humans and other organisms show age-related signs of deterioration, which makes aging an interesting process to study. In the present work, we review the anti-aging evidence of several of the most promising natural compounds. Quercetin, rapamycin, resveratrol, spermidine, curcumin or sulforaphane administration increase longevity and stress resistance in model organisms such as yeasts, nematodes, flies and mice. Even more, rapamycin, resveratrol, and curcumin are currently in preclinical tests on the Interventions Testing Program of the National Institute on Aging due to their encouraging results in model organisms. The potential mechanisms underlying the beneficial effects of these compounds are briefly described.

Keywords: Aging models; Longevity; Natural compounds; Signaling pathways; Stress resistance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological / drug effects*
  • Adaptation, Physiological / physiology
  • Aging* / drug effects
  • Aging* / physiology
  • Animals
  • Biological Products* / metabolism
  • Biological Products* / pharmacology
  • Humans
  • Longevity* / drug effects
  • Longevity* / physiology
  • Models, Biological
  • Signal Transduction / drug effects*
  • Signal Transduction / physiology


  • Biological Products