Utilizing platelet-rich fibrin bioscaffold at the graft site improves the structure and function of mice ovarian grafts

Regen Med. 2019 May;14(5):409-422. doi: 10.2217/rme-2018-0050. Epub 2019 Jun 12.


Aim: The effect of platelet-rich fibrin (PRF) bioscaffold on the structure and function of mice-autotransplanted ovaries was investigated. Materials & methods: Mice were divided into three groups: control, autografted and autografted + PRF bioscaffold. Angiogenesis, ovary histology and serum biochemical factors were assessed. Results: The total volume of the ovary, the number of follicles and the level of superoxide dismutase activity, total antioxidant capacity, IL-10, progesterone and estradiol were significantly higher in the autografted + PRF bioscaffold group compared with the autografted group. In the autografted + PRF bioscaffold group, angiogenesis was accelerated and apoptosis rate, IL-6, TNF-α, malondialdehyde concentrations were significantly lower compared with the autografted group. Conclusion: PRF bioscaffold improves the structure and function of mice-autografted ovary.

Keywords: angiogenesis; apoptosis; autotransplantation; inflammation; ischemia; mice; ovary; oxidative stress; platelet-rich fibrin bioscaffold; stereology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis
  • Cytokines / metabolism
  • Female
  • Mice
  • Neovascularization, Physiologic
  • Organ Transplantation*
  • Ovary* / metabolism
  • Ovary* / transplantation
  • Platelet-Rich Fibrin*
  • Transplantation, Autologous


  • Cytokines