The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P2

J Cell Biol. 2019 Jul 1;218(7):2082-2083. doi: 10.1083/jcb.201906022. Epub 2019 Jun 12.

Abstract

Loss of the phosphoinositide 5-phosphatase OCRL causes accumulation of PtdIns(4,5)P2 on membranes and, ultimately, Lowe syndrome. In this issue, Mondin et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201805155) discover that a surprising partnership between PTEN and the phospholipase PLCXD can compensate for OCRL to suppress endosomal PtdIns(4,5)P2 accumulation.

Publication types

  • Comment

MeSH terms

  • Endosomes
  • Humans
  • Oculocerebrorenal Syndrome*
  • PTEN Phosphohydrolase
  • Phosphatidylinositol 4,5-Diphosphate
  • Phosphatidylinositols*
  • Phosphoric Monoester Hydrolases

Substances

  • Phosphatidylinositol 4,5-Diphosphate
  • Phosphatidylinositols
  • Phosphoric Monoester Hydrolases
  • PTEN Phosphohydrolase
  • PTEN protein, human