Lymphatic Migration of Immune Cells

Front Immunol. 2019 May 28:10:1168. doi: 10.3389/fimmu.2019.01168. eCollection 2019.


Lymphatic vessels collect interstitial fluid that has extravasated from blood vessels and return it to the circulatory system. Another important function of the lymphatic network is to facilitate immune cell migration and antigen transport from the periphery to draining lymph nodes. This migration plays a crucial role in immune surveillance, initiation of immune responses and tolerance. Here we discuss the significance and mechanisms of lymphatic migration of innate and adaptive immune cells in homeostasis, inflammation and cancer.

Keywords: T cells; dendritic cells; lymphatic; migration; neutrophils.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity
  • Animals
  • Cell Movement*
  • Dendritic Cells / cytology
  • Dendritic Cells / immunology
  • Dendritic Cells / metabolism
  • Disease Susceptibility
  • Humans
  • Immune System / cytology*
  • Immune System / physiology*
  • Immunity, Innate
  • Lymphatic Vessels*
  • Neutrophils / cytology
  • Neutrophils / immunology
  • Neutrophils / metabolism
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism