Nitrous oxide cryotherapy for the management of benign lesions of the oral cavity

J Oral Pathol Med. 2019 Aug;48(7):611-618. doi: 10.1111/jop.12912. Epub 2019 Jun 25.

Abstract

Background: Cryotherapy is the deliberate destruction of tissue by the application of extreme cold, and has been indicated as a treatment modality for the management of commonly occurring benign oral pathologies. The aim of this study was to investigate treatment protocol parameters and effectiveness of a closed cryotherapy system for the management of oral mucoceles and vascular malformations.

Methods: This retrospective study analyzed data collected from a specialist oral medicine clinic referred for treatment of oral mucoceles or vascular malformations. Data was analyzed to determine lesion characteristics, treatment parameters, and clinical effectiveness of a closed cryotherapy system.

Results: The closed cryotherapy system achieved 100% success rate in lesion resolution. For both pathologies, increased lesion diameter was related to increased number of cryotherapy appointments, increased number of freeze cycles, and increased cumulative freeze time. 95% of vascular malformations and 83.34% of mucoceles resolved with no signs of post-operative complication, and patients did not report postoperative pain.

Conclusions: Cryotherapy is an excellent treatment option for benign lesion management. It is minimally invasive, causes minimal discomfort, and has a high rate of clinical success.

Keywords: benign lesions; cryotherapy; mucocele; nitrous oxide; vascular malformation.

MeSH terms

  • Cryotherapy*
  • Humans
  • Mouth Diseases* / therapy
  • Nitrous Oxide
  • Retrospective Studies

Substances

  • Nitrous Oxide