The complexity of serotype replacement of pneumococci

Hum Vaccin Immunother. 2019;15(11):2725-2728. doi: 10.1080/21645515.2019.1621068. Epub 2019 Jun 13.


Pneumococci respond extremely rapidly to the vaccine pressure created by the conjugate vaccines (PCVs). Vaccine serotypes are disappearing, meanwhile new, often previously very rare types are emerging, and it is difficult to establish what makes certain serotypes more successful in replacement. The situation is very complex: every serotype has different antibiotic sensitivity or invasive capacity. However, despite this dynamic serotype rearrangement, the overall pneumococcal carriage rate remains quite stable, suggesting that these bacterial species can be considered as a commensal colonizer.

Keywords: IPD; Pneumococcal conjugate vaccines; antibiotic resistance; carriage; serotypes.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Carrier State / immunology
  • Carrier State / microbiology*
  • Drug Resistance, Bacterial
  • Humans
  • Pneumococcal Infections / immunology*
  • Pneumococcal Infections / prevention & control
  • Pneumococcal Vaccines / immunology*
  • Serogroup
  • Serotyping
  • Streptococcus pneumoniae / classification*
  • Streptococcus pneumoniae / drug effects
  • Vaccines, Conjugate / immunology


  • Anti-Bacterial Agents
  • Pneumococcal Vaccines
  • Vaccines, Conjugate