Neutrophil-to-lymphocyte ratio (NLR) fails to predict outcome of diffuse large B cell lymphoma

Yoshiko Azuma; Aya Nakaya; Shinya Fujita; Atsushi Satake; Takahisa Nakanishi; Yukie Tsubokura; Ryo Saito; Akiko Konishi; Masaaki Hotta; Hideaki Yoshimura; Kazuyoshi Ishii; Tomoki Ito; Shosaku Nomura

doi:10.1016/j.lrr.2019.100173

Neutrophil-to-lymphocyte ratio (NLR) fails to predict outcome of diffuse large B cell lymphoma

Leuk Res Rep. 2019 May 25:12:100173. doi: 10.1016/j.lrr.2019.100173. eCollection 2019.

Affiliation

¹ First Department of Internal Medicine, Kansai Medical University, 2-5-1, Shin-machi, Hirakata, Osaka 573-1010, Japan.

Abstract

Background: Neutrophil-to-lymphocyte ratio (NLR) has been recognized as a poor prognostic indicator in various solid tumors.

Methods: We retrospectively analyzed 530 patients with de novo DLBCL who were diagnosed from April 2002 to November 2017.

Results: The median age of patients was 69 (range, 20-95) years, and 59% were male. The optimal cutoff for NLR was 5.2. NLR (5.2) was not associated with overall and progression free survival.

Conclusion: Our study failed to reveal the predictive value of NLR and demonstrated that the NCCN-IPI might be the most powerful predictor in DLBCL.

Keywords: Diffuse large B cell lymphoma; NCCN-IPI; Neutrophil-to-lymphocyte ratio.