Doxepin

Excerpt

Doxepin belongs to the class of tricyclic antidepressant medications approved by the US Food and Drug Administration (FDA) for the treatment of major depressive disorder, anxiety, and insomnia, as well as for managing skin pruritus. Doxepin functions by increasing the concentration of the neurotransmitter serotonin (5-hydroxytryptamine or 5-HT) and norepinephrine (NE) in the brain. This mechanism extends the availability of the neurotransmitters (5-HT and NE) within the synaptic cleft and enhances their neurotransmission by preventing their reuptake into the presynaptic terminal.