New perspectives on screening and early detection of endometrial cancer

Int J Cancer. 2019 Dec 15;145(12):3194-3206. doi: 10.1002/ijc.32514. Epub 2019 Jun 28.


Due to the anatomical continuity of the uterine cavity with the cervix, genomic exploitation of material from routine Pap smears and other noninvasive sampling methods represent a unique opportunity to detect signs of disease using biological material shed from the upper genital tract. Recent research findings offer a promising perspective in the detection of endometrial cancer, but certain questions need to be addressed in order to accelerate the implementation of novel technologies in a routine screening or clinical setting. We discuss here new perspectives on detection of endometrial cancer using genomic and other biomarkers in minimally invasive sampling methods with a special focus on public health classic screening criteria, highlighting current gaps in knowledge.

Keywords: biomarkers; early detection; endometrial cancer; genomics; pap smears; screening.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers, Tumor / genetics
  • Early Detection of Cancer / methods
  • Endometrial Neoplasms / diagnosis*
  • Endometrial Neoplasms / genetics
  • Female
  • Humans
  • Mass Screening / methods


  • Biomarkers, Tumor