Autophagy-Independent Functions of the Autophagy Machinery

Cell. 2019 Jun 13;177(7):1682-1699. doi: 10.1016/j.cell.2019.05.026.


Macroautophagy (herein referred to as autophagy) is an evolutionary ancient mechanism that culminates with the lysosomal degradation of superfluous or potentially dangerous cytosolic entities. Over the past 2 decades, the molecular mechanisms underlying several variants of autophagy have been characterized in detail. Accumulating evidence suggests that most, if not all, components of the molecular machinery for autophagy also mediate autophagy-independent functions. Here, we discuss emerging data on the non-autophagic functions of autophagy-relevant proteins.

Keywords: ATG5; BECN1; LC3-associated phagocytosis; proliferation; regulated cell death; vesicular trafficking.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Autophagy / physiology*
  • Autophagy-Related Proteins / metabolism*
  • Humans
  • Lysosomes / metabolism*


  • Autophagy-Related Proteins