Reactive nitrogen species in host-bacterial interactions

doi:10.1016/j.coi.2019.05.008

Review

. 2019 Oct:60:96-102.

doi: 10.1016/j.coi.2019.05.008. Epub 2019 Jun 12.

Reactive nitrogen species in host-bacterial interactions

Ferric C Fang¹, Andrés Vázquez-Torres²

Affiliations

¹ Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195-7735, USA; Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195-7110, USA. Electronic address: fcfang@uw.edu.
² Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA; Veterans Affairs Eastern Colorado Health Care System, Denver, CO 80220, USA.

PMID: 31200187
PMCID: PMC6800629
DOI: 10.1016/j.coi.2019.05.008

Review

Reactive nitrogen species in host-bacterial interactions

Ferric C Fang et al. Curr Opin Immunol. 2019 Oct.

. 2019 Oct:60:96-102.

doi: 10.1016/j.coi.2019.05.008. Epub 2019 Jun 12.

Authors

Ferric C Fang¹, Andrés Vázquez-Torres²

Affiliations

¹ Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195-7735, USA; Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195-7110, USA. Electronic address: fcfang@uw.edu.
² Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA; Veterans Affairs Eastern Colorado Health Care System, Denver, CO 80220, USA.

PMID: 31200187
PMCID: PMC6800629
DOI: 10.1016/j.coi.2019.05.008

Abstract

Reactive nitrogen species play diverse and essential roles in host-pathogen interactions. Here, we review selected recent discoveries regarding nitric oxide (NO) in host defense and the pathogenesis of infection, mechanisms of bacterial NO resistance, production of NO by human macrophages, NO-based antimicrobial therapeutics and NO interactions with the gut microbiota.

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Conflict of interest statement

Declarations of Interest: None.

Figures

**Figure 1.. Diverse Actions of Nitric Oxide in Host-Bacterial Interactions.**
Some important actions of NO are shown. Please refer to the text for details.

See this image and copyright information in PMC

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References

1. Cunningham R, Mustoe E, Spiller L, Lewis S Benjamin N: Acidified nitrite: a host defence against colonization with C. difficile spores. J Hosp Infect 2014, 86:155–157.
  * Clostridioides (Clostridium) difficile spores are resistant to acid but susceptible to acidified nitrite generated in the stomach, which may account for the increased susceptibility of individuals receiving proton pump inhibitors.
1. MacMicking JD, North RJ, LaCourse R, Mudgett JS, Shah SK Nathan CF: Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acad Sci U S A 1997, 94:5243–5248. - PMC - PubMed
1. Mastroeni P, Vazquez-Torres A, Fang FC, Xu Y, Khan S, Hormaeche CE Dougan G: Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo. J Exp Med 2000, 192:237–248. - PMC - PubMed
1. Fang FC: Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Nat Rev Microbiol 2004, 2:820–832. - PubMed
1. Henard CA Vázquez-Torres A: Nitric oxide and Salmonella pathogenesis. Front Microbiol 2011, 2:84. - PMC - PubMed

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[1] Cunningham R, Mustoe E, Spiller L, Lewis S Benjamin N: Acidified nitrite: a host defence against colonization with C. difficile spores. J Hosp Infect 2014, 86:155–157.
* Clostridioides (Clostridium) difficile spores are resistant to acid but susceptible to acidified nitrite generated in the stomach, which may account for the increased susceptibility of individuals receiving proton pump inhibitors.

[2] Cunningham R, Mustoe E, Spiller L, Lewis S Benjamin N: Acidified nitrite: a host defence against colonization with C. difficile spores. J Hosp Infect 2014, 86:155–157.
* Clostridioides (Clostridium) difficile spores are resistant to acid but susceptible to acidified nitrite generated in the stomach, which may account for the increased susceptibility of individuals receiving proton pump inhibitors.

[3] MacMicking JD, North RJ, LaCourse R, Mudgett JS, Shah SK Nathan CF: Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acad Sci U S A 1997, 94:5243–5248. - PMC - PubMed

[4] MacMicking JD, North RJ, LaCourse R, Mudgett JS, Shah SK Nathan CF: Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acad Sci U S A 1997, 94:5243–5248. - PMC - PubMed

[5] Mastroeni P, Vazquez-Torres A, Fang FC, Xu Y, Khan S, Hormaeche CE Dougan G: Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo. J Exp Med 2000, 192:237–248. - PMC - PubMed

[6] Mastroeni P, Vazquez-Torres A, Fang FC, Xu Y, Khan S, Hormaeche CE Dougan G: Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo. J Exp Med 2000, 192:237–248. - PMC - PubMed

[7] Fang FC: Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Nat Rev Microbiol 2004, 2:820–832. - PubMed

[8] Fang FC: Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Nat Rev Microbiol 2004, 2:820–832. - PubMed

[9] Henard CA Vázquez-Torres A: Nitric oxide and Salmonella pathogenesis. Front Microbiol 2011, 2:84. - PMC - PubMed

[10] Henard CA Vázquez-Torres A: Nitric oxide and Salmonella pathogenesis. Front Microbiol 2011, 2:84. - PMC - PubMed

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Reactive nitrogen species in host-bacterial interactions

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Reactive nitrogen species in host-bacterial interactions

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