Dipeptide Mimetic of the BDNF Loop 4 Possesses Analgetic Activity

Dokl Biochem Biophys. 2019 Mar;485(1):123-125. doi: 10.1134/S1607672919020121. Epub 2019 Jun 14.

Abstract

Previously, we synthesized a dimeric dipeptide mimetic of the brain-derived neurotrophic factor (BDNF) loop 4, GSB-106, which, similarly to BDNF, activated TrkB, PI3K/AKT, and MAPK/ERK. When administered systemically, it exhibited neuroprotective, antidepressant, and antidiabetic activities and stimulated neurogenesis and synaptogenesis. In this study, we established that GSB-106 also exhibits the analgesic activity, typical for BDNF, which was revealed in rats in hot plate and tail flick tests 0.5-48 h after intraperitoneal injection at doses of 0.1 and 1 mg/kg.

MeSH terms

  • Analgesics* / chemistry
  • Analgesics* / pharmacology
  • Animals
  • Brain-Derived Neurotrophic Factor* / chemistry
  • Brain-Derived Neurotrophic Factor* / pharmacology
  • Dipeptides* / chemistry
  • Dipeptides* / pharmacology
  • Humans
  • Male
  • Peptidomimetics* / chemistry
  • Peptidomimetics* / pharmacology
  • Protein Structure, Secondary
  • Rats

Substances

  • Analgesics
  • Brain-Derived Neurotrophic Factor
  • Dipeptides
  • Peptidomimetics