The Endocannabinoid System and its Modulation by Cannabidiol (CBD)

Altern Ther Health Med. 2019 Jun;25(S2):6-14.


The endocannabinoid system (ECS) is an extensive endogenous signaling system with multiple elements, the number of which may be increasing as scientists continue to elucidate its role in human health and disease. The ECS is seemingly ubiquitous in animal species and is modulated by diet, sleep, exercise, stress, and a multitude of other factors, including exposure to phytocannabinoids, like Cannabidiol (CBD). Modulating the activity of this system may offer tremendous therapeutic promise for a diverse scope of diseases, ranging from mental health disorders, neurological and movement disorders, pain, autoimmune disease, spinal cord injury, cancer, cardiometabolic disease, stroke, TBI, osteoporosis, and others.

MeSH terms

  • Animals
  • Cannabidiol / pharmacology*
  • Endocannabinoids*
  • Humans
  • Mental Disorders
  • Pain
  • Signal Transduction


  • Endocannabinoids
  • Cannabidiol