Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 86 (6), 433-442

Genetics of Resilience: Gene-by-Environment Interaction Studies as a Tool to Dissect Mechanisms of Resilience

Affiliations
Review

Genetics of Resilience: Gene-by-Environment Interaction Studies as a Tool to Dissect Mechanisms of Resilience

Immanuel G Elbau et al. Biol Psychiatry.

Abstract

The identification and understanding of resilience mechanisms holds potential for the development of mechanistically informed prevention and interventions in psychiatry. However, investigating resilience mechanisms is conceptually and methodologically challenging because resilience does not merely constitute the absence of disease-specific risk but rather reflects active processes that aid in the maintenance of physiological and psychological homeostasis across a broad range of environmental circumstances. In this conceptual review, we argue that the principle used in gene-by-environment interaction studies may help to unravel resilience mechanisms on different investigation levels. We present how this could be achieved by top-down designs that start with gene-by-environment interaction effects on disease phenotypes as well as by bottom-up approaches that start at the molecular level. We also discuss how recent technological advances may improve both top-down and bottom-up strategies.

Keywords: Epigenetics; Gene-by-environment interactions; Genetics; Psychiatry; Resilience; Stress.

Similar articles

See all similar articles

Cited by 1 PubMed Central articles

  • Resilience In Dogs? Lessons From Other Species
    K Tiira. Vet Med (Auckl) 10, 159-168. PMID 31815099. - Review
    What are the key factors of psychological resilience in dogs? Why do some individuals recover swiftly from neglect, abuse or several years of harsh kennel environments, w …

LinkOut - more resources

Feedback