The identification and understanding of resilience mechanisms holds potential for the development of mechanistically informed prevention and interventions in psychiatry. However, investigating resilience mechanisms is conceptually and methodologically challenging because resilience does not merely constitute the absence of disease-specific risk but rather reflects active processes that aid in the maintenance of physiological and psychological homeostasis across a broad range of environmental circumstances. In this conceptual review, we argue that the principle used in gene-by-environment interaction studies may help to unravel resilience mechanisms on different investigation levels. We present how this could be achieved by top-down designs that start with gene-by-environment interaction effects on disease phenotypes as well as by bottom-up approaches that start at the molecular level. We also discuss how recent technological advances may improve both top-down and bottom-up strategies.
Keywords: Epigenetics; Gene-by-environment interactions; Genetics; Psychiatry; Resilience; Stress.
Copyright © 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
Epigenetics at the Crossroads Between Genes, Environment and Resilience in Anxiety DisordersMA Schiele et al. Genes Brain Behav 17 (3), e12423. PMID 28873274. - ReviewThe pathogenesis of anxiety disorders is multifactorial, involving complex interactions between biological factors, environmental influences and psychological mechanisms. …
The Biology of Human Resilience: Opportunities for Enhancing Resilience Across the Life SpanA Feder et al. Biol Psychiatry 86 (6), 443-453. PMID 31466561. - ReviewRecent scientific and technological advances have brought us closer to being able to apply a true biopsychosocial approach to the study of resilience in humans. Decades o …
Understanding Resilience: New Approaches for Preventing and Treating PTSDSR Horn et al. Exp Neurol 284 (Pt B), 119-132. PMID 27417856. - ReviewAll individuals experience stressful life events, and up to 84% of the general population will experience at least one potentially traumatic event. In some cases, acute o …
Implications of Resilience Concepts for Scientific UnderstandingM Rutter. Ann N Y Acad Sci 1094, 1-12. PMID 17347337. - ReviewResilience is an interactive concept that refers to a relative resistance to environmental risk experiences, or the overcoming of stress or adversity. As such, it differs …
A Systematic Review of Genetic Influence on Psychological ResilienceK Niitsu et al. Biol Res Nurs 21 (1), 61-71. PMID 30223673.When exposed to adversity, some individuals are at an increased risk of posttraumatic stress disorder, experiencing persistent biopsychosocial disturbances, whereas other …
Cited by 1 PubMed Central articles
Resilience In Dogs? Lessons From Other SpeciesK Tiira. Vet Med (Auckl) 10, 159-168. PMID 31815099. - ReviewWhat are the key factors of psychological resilience in dogs? Why do some individuals recover swiftly from neglect, abuse or several years of harsh kennel environments, w …