Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

doi:10.1016/j.cmet.2019.05.014

. 2019 Jul 2;30(1):1-2.

doi: 10.1016/j.cmet.2019.05.014. Epub 2019 Jun 13.

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

Affiliations

¹ Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands; Department of Vascular Medicine, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands.
² Department of Vascular Medicine, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands.
³ Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, 3052 Victoria, Australia.
⁴ Experimental Vascular Biology, Department of Medical Biochemistry, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands.
⁵ Department of Internal Medicine, Erasmus University Medical Center, 3015GD Rotterdam, the Netherlands.
⁶ Department of Molecular Biology, RIMLS, Radboud University Medical Center, Nijmegen 6525GA, the Netherlands.
⁷ Experimental Vascular Biology, Department of Medical Biochemistry, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands; Institute for Cardiovascular Prevention (IPEK), 80336 Munich, Germany.
⁸ Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands; Department of Medical Genetics, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.
⁹ Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands; Department for Immunology & Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.
¹⁰ Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands. Electronic address: niels.riksen@radboudumc.nl.

PMID: 31204280
DOI: 10.1016/j.cmet.2019.05.014

Free article

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

Siroon Bekkering et al. Cell Metab. 2019.

Free article

. 2019 Jul 2;30(1):1-2.

doi: 10.1016/j.cmet.2019.05.014. Epub 2019 Jun 13.

Affiliations

¹ Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands; Department of Vascular Medicine, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands.
² Department of Vascular Medicine, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands.
³ Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, 3052 Victoria, Australia.
⁴ Experimental Vascular Biology, Department of Medical Biochemistry, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands.
⁵ Department of Internal Medicine, Erasmus University Medical Center, 3015GD Rotterdam, the Netherlands.
⁶ Department of Molecular Biology, RIMLS, Radboud University Medical Center, Nijmegen 6525GA, the Netherlands.
⁷ Experimental Vascular Biology, Department of Medical Biochemistry, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands; Institute for Cardiovascular Prevention (IPEK), 80336 Munich, Germany.
⁸ Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands; Department of Medical Genetics, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.
⁹ Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands; Department for Immunology & Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.
¹⁰ Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands. Electronic address: niels.riksen@radboudumc.nl.

PMID: 31204280
DOI: 10.1016/j.cmet.2019.05.014

Abstract

Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lipid lowering with statins does not revert this pro-inflammatory phenotype.

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Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

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Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

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