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Review
. 2019 Apr 2;10(7):1663-1674.
doi: 10.7150/jca.28231. eCollection 2019.

The Expression, Functions, Interactions and Prognostic Values of PTPRZ1: A Review and Bioinformatic Analysis

Zhenkun Xia  1 , Dengjie Ouyang  2 , Qianying Li  2 , Moyun Li  2 , Qiongyan Zou  2 , Lun Li  3 , Wenjun Yi  2 , Enxiang Zhou  2
Affiliations
Review

The Expression, Functions, Interactions and Prognostic Values of PTPRZ1: A Review and Bioinformatic Analysis

Zhenkun Xia et al. J Cancer. .

Abstract

Available studies demonstrate that receptor-type tyrosine-protein phosphatase zeta (PTPRZ1) is expressed in different tumor tissues, and functions in cell proliferation, cell adhesion and migration, epithelial-to-mesenchymal transition, cancer stem cells and treatment resistance by interacting with or binding to several molecules. These included pleiotrophin (PTN), midkine, interleukin-34, β-catenin, VEGF, NF-κB, HIF-2, PSD-95, MAGI-3, contactin and ErbB4. PTPRZ1 was involved in survival signaling and could predict the prognosis of several tumors. This review discusses: the current knowledge about PTPRZ1, its expression, co-receptors, ligands, functions, signaling pathway, prognostic values and therapeutic agents that target PTPRZ1.

Keywords: PTPRZ1; midkine; pleiotrophin; review.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
The expression levels of PTPRZ1 based on TCGA data (Log2(TPM + 1) Scale)
Figure 2
Figure 2
The rates of PTPRZ1 mutations based on TCGA data
Figure 3
Figure 3
Relevant molecules that interacted with PTPRZ1 from Cytoscape_3.6.0 (figure 3).
Figure 4
Figure 4
Network based on the literatures we reviewed
Figure 5
Figure 5
Signaling pathway based on the literatures we reviewed
Figure 6
Figure 6
Survival plot based on TCGA data (the plot was drawn when p<0.05)
See this image and copyright information in PMC

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