Babesiosis is an infectious disease caused by protozoa of the genus Babesia. Its incidence has been increasing in the Northeast and upper Midwest regions of the United States in recent years. Symptoms of babesiosis can range from a mild flu-like illness to acute, severe, and fatal disease. Severe disease is common in older populations and immunocompromised patients. The laboratory abnormalities associated with babesiosis, such as low hematocrit, low hemoglobin, elevated lactate dehydrogenase, low haptoglobin, reticulocytosis, the presence of schistocytes on the peripheral blood smear and thrombocytopenia, can mimic other severe systemic disorders like thrombotic thrombocytopenic purpura (TTP). Hence, it is crucial to be aware of babesiosis, especially in highly endemic areas as it can masquerade as severe fatal systemic diseases like TTP.
Keywords: babesiosis; microangiopathic hemolytic anemia.
Conflict of interest statement
The authors have declared that no competing interests exist.
Thrombotic Thrombocytopenic Purpura Without Schistocytes on the Peripheral Blood SmearSR Daram et al. South Med J 98 (3), 392-5. PMID 15813170. - Case ReportsA hallmark of the clinical syndrome of thrombotic thrombocytopenic purpura (TTP) is evidence of microangiopathic hemolytic anemia. The presence of schistocytes on the per …
When the Picture Is Fragmented: Vitamin B12 Deficiency Masquerading as Thrombotic Thrombocytopenic PurpuraTS Panchabhai et al. Int J Crit Illn Inj Sci 6 (2), 89-92. PMID 27308258. - Case ReportsThrombotic thrombocytopenic purpura (TTP) has high mortality and necessitates prompt recognition of microangiopathic hemolytic anemia (MAHA) and initiation of plasmaphere …
Pseudo-thrombotic Thrombocytopenic Purpura: A Rare Presentation of Pernicious AnemiaAK Tadakamalla et al. N Am J Med Sci 3 (10), 472-4. PMID 22363087. - Case ReportsClinicians must be aware of unusual clinical presentation of vitamin B(12) deficiency with schistocytes as the management is simple and effective.
Systemic Lupus Erythematosus Presenting as Refractory Thrombotic Thrombocytopenic Purpura: A Diagnostic and Management Challenge. A Case Report and Concise Review of the LiteratureM Abu-Hishmeh et al. Am J Case Rep 17, 782-787. PMID 27777394. - ReviewBACKGROUND Thrombotic thrombocytopenic purpura (TTP) is one of the thrombotic microangiopathic (TMA) syndromes, caused by severely reduced activity of the vWF-cleaving pr …
Thrombotic Thrombocytopenic Purpura: Pathogenesis, Diagnosis and Potential Novel TherapeuticsM Saha et al. J Thromb Haemost 15 (10), 1889-1900. PMID 28662310. - ReviewThrombotic thrombocytopenic purpura (TTP), a potentially fatal clinical syndrome, is primarily caused by autoantibodies against the von Willebrand factor (VWF)-cleaving m …
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