Use of Directly Observed Therapy to Assess Treatment Adherence in Patients With Apparent Treatment-Resistant Hypertension

doi:10.1001/jamainternmed.2019.1455

. 2019 Oct 1;179(10):1433-1434.

doi: 10.1001/jamainternmed.2019.1455.

Use of Directly Observed Therapy to Assess Treatment Adherence in Patients With Apparent Treatment-Resistant Hypertension

Marcel Ruzicka^{1

2

3}, Frans H H Leenen⁴, Tim Ramsay², Ann Bugeja^{1

3}, Cedric Edwards^{1

3}, Brendan McCormick^{1

3}, Swapnil Hiremath^{1

2

3}

Affiliations

¹ Renal Hypertension Center, Division of Nephrology, University of Ottawa, Ottawa, Ontario, Canada.
² Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
³ Kidney Research Center, University of Ottawa, Ottawa, Ontario, Canada.
⁴ Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

PMID: 31206124
PMCID: PMC6580437
DOI: 10.1001/jamainternmed.2019.1455

Use of Directly Observed Therapy to Assess Treatment Adherence in Patients With Apparent Treatment-Resistant Hypertension

Marcel Ruzicka et al. JAMA Intern Med. 2019.

. 2019 Oct 1;179(10):1433-1434.

doi: 10.1001/jamainternmed.2019.1455.

Authors

Marcel Ruzicka^{1

2

3}, Frans H H Leenen⁴, Tim Ramsay², Ann Bugeja^{1

3}, Cedric Edwards^{1

3}, Brendan McCormick^{1

3}, Swapnil Hiremath^{1

2

3}

Affiliations

¹ Renal Hypertension Center, Division of Nephrology, University of Ottawa, Ottawa, Ontario, Canada.
² Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
³ Kidney Research Center, University of Ottawa, Ottawa, Ontario, Canada.
⁴ Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

PMID: 31206124
PMCID: PMC6580437
DOI: 10.1001/jamainternmed.2019.1455

Abstract

This cohort study evaluates the association of directly observed therapy with treatment adherencee in patients with apparent treatment-resistant hypertension.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Ruzicka reported receiving grants from Physicians Services Incorporated and The Ottawa Hospital Academic Medical Organization–Innovation Fund Provincial Oversight Committee during the conduct of the study. Dr Hiremath reported receiving grants from the Canadian Institutes of Health Research, Physicians Services Incorporated, and The Ottawa Hospital Academic Medical Organization outside the submitted work. No other disclosures were reported.

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References

1. Burnier M, Wuerzner G, Struijker-Boudier H, Urquhart J. Measuring, analyzing, and managing drug adherence in resistant hypertension. Hypertension. 2013;62(2):218-225. doi:10.1161/HYPERTENSIONAHA.113.00687 - DOI - PubMed
1. Fadl Elmula FE, Hoffmann P, Larstorp AC, et al. . Adjusted drug treatment is superior to renal sympathetic denervation in patients with true treatment-resistant hypertension. Hypertension. 2014;63(5):991-999. doi:10.1161/HYPERTENSIONAHA.114.03246 - DOI - PubMed
1. Ruzicka M, Hiremath S. Can drugs work in patients who do not take them? the problem of non-adherence in resistant hypertension. Curr Hypertens Rep. 2015;17(9):579. doi:10.1007/s11906-015-0579-4 - DOI - PubMed
1. Ruzicka M, McCormick B, Leenen FH, Froeschl M, Hiremath S. Adherence to blood pressure-lowering drugs and resistant hypertension: should trial of direct observation therapy be part of preassessment for renal denervation? Can J Cardiol. 2013;29(12):1741.e1-1741.e3. doi:10.1016/j.cjca.2013.07.678 - DOI - PubMed
1. Brinker S, Pandey A, Ayers C, et al. . Therapeutic drug monitoring facilitates blood pressure control in resistant hypertension. J Am Coll Cardiol. 2014;63(8):834-835. doi:10.1016/j.jacc.2013.10.067 - DOI - PMC - PubMed

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[1] Burnier M, Wuerzner G, Struijker-Boudier H, Urquhart J. Measuring, analyzing, and managing drug adherence in resistant hypertension. Hypertension. 2013;62(2):218-225. doi:10.1161/HYPERTENSIONAHA.113.00687 - DOI - PubMed

[2] Burnier M, Wuerzner G, Struijker-Boudier H, Urquhart J. Measuring, analyzing, and managing drug adherence in resistant hypertension. Hypertension. 2013;62(2):218-225. doi:10.1161/HYPERTENSIONAHA.113.00687 - DOI - PubMed

[3] Fadl Elmula FE, Hoffmann P, Larstorp AC, et al. . Adjusted drug treatment is superior to renal sympathetic denervation in patients with true treatment-resistant hypertension. Hypertension. 2014;63(5):991-999. doi:10.1161/HYPERTENSIONAHA.114.03246 - DOI - PubMed

[4] Fadl Elmula FE, Hoffmann P, Larstorp AC, et al. . Adjusted drug treatment is superior to renal sympathetic denervation in patients with true treatment-resistant hypertension. Hypertension. 2014;63(5):991-999. doi:10.1161/HYPERTENSIONAHA.114.03246 - DOI - PubMed

[5] Ruzicka M, Hiremath S. Can drugs work in patients who do not take them? the problem of non-adherence in resistant hypertension. Curr Hypertens Rep. 2015;17(9):579. doi:10.1007/s11906-015-0579-4 - DOI - PubMed

[6] Ruzicka M, Hiremath S. Can drugs work in patients who do not take them? the problem of non-adherence in resistant hypertension. Curr Hypertens Rep. 2015;17(9):579. doi:10.1007/s11906-015-0579-4 - DOI - PubMed

[7] Ruzicka M, McCormick B, Leenen FH, Froeschl M, Hiremath S. Adherence to blood pressure-lowering drugs and resistant hypertension: should trial of direct observation therapy be part of preassessment for renal denervation? Can J Cardiol. 2013;29(12):1741.e1-1741.e3. doi:10.1016/j.cjca.2013.07.678 - DOI - PubMed

[8] Ruzicka M, McCormick B, Leenen FH, Froeschl M, Hiremath S. Adherence to blood pressure-lowering drugs and resistant hypertension: should trial of direct observation therapy be part of preassessment for renal denervation? Can J Cardiol. 2013;29(12):1741.e1-1741.e3. doi:10.1016/j.cjca.2013.07.678 - DOI - PubMed

[9] Brinker S, Pandey A, Ayers C, et al. . Therapeutic drug monitoring facilitates blood pressure control in resistant hypertension. J Am Coll Cardiol. 2014;63(8):834-835. doi:10.1016/j.jacc.2013.10.067 - DOI - PMC - PubMed

[10] Brinker S, Pandey A, Ayers C, et al. . Therapeutic drug monitoring facilitates blood pressure control in resistant hypertension. J Am Coll Cardiol. 2014;63(8):834-835. doi:10.1016/j.jacc.2013.10.067 - DOI - PMC - PubMed

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Use of Directly Observed Therapy to Assess Treatment Adherence in Patients With Apparent Treatment-Resistant Hypertension

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Use of Directly Observed Therapy to Assess Treatment Adherence in Patients With Apparent Treatment-Resistant Hypertension

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