Cold atmospheric plasma promotes different types of superficial skin erosion wounds healing

Int Wound J. 2019 Oct;16(5):1103-1111. doi: 10.1111/iwj.13161. Epub 2019 Jun 17.


Superficial skin erosion wounds are very common in the clinic, and conventional treatments are not always effective; thus, effective and novel therapy is needed. Cold atmospheric plasma (CAP) has been recognised as a promising approach to wound healing. The purpose of this study is to show the potential clinical application of CAP for the healing of different kinds of superficial skin wounds. Seven patients with different kinds of superficial skin wounds (two patients with pyoderma gangrenosum, two patients with trauma would, one patient with giant genital wart, one patient with diabetic foot, and one patient with chronic eczema) were recruited to this study. All patients accepted and received CAP treatment every other day till the wound healed. The expected results were complete wound healing after CAP treatment. All patients achieved complete wound healing after several rounds (range from two to eight) of CAP treatment, and there was no side effect observed. CAP may provide a new and effective choice to solve the problem of the healing of superficial wounds that are not only caused by trauma but also because of eczema. CAP has certain value in the treatment of superficial skin diseases in the future.

Keywords: cold atmospheric plasma; skin lesion; traumatic wound.

MeSH terms

  • Adult
  • Aged
  • Diabetic Foot / diagnosis
  • Diabetic Foot / therapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Plasma Gases / therapeutic use*
  • Prognosis
  • Retrospective Studies
  • Sampling Studies
  • Severity of Illness Index
  • Skin Ulcer / diagnosis
  • Skin Ulcer / therapy*
  • Treatment Outcome
  • Wound Healing / physiology*
  • Wounds and Injuries / diagnosis
  • Wounds and Injuries / surgery*
  • Young Adult


  • Plasma Gases