Lifespan normative data on rates of brain volume changes

Neurobiol Aging. 2019 Sep;81:30-37. doi: 10.1016/j.neurobiolaging.2019.05.010. Epub 2019 May 22.

Abstract

We provide here normative values of yearly percentage brain volume change (PBVC/y) as obtained with Structural Imaging Evaluation, using Normalization, of Atrophy, a widely used open-source software, developing a PBVC/y calculator for assessing the deviation from the expected PBVC/y in patients with neurological disorders. We assessed multicenter (34 centers, 11 acquisition protocols) magnetic resonance imaging data of 720 healthy participants covering the whole adult lifespan (16-90 years). Data of 421 participants with a follow-up > 6 months were used to obtain the normative values for PBVC/y and data of 392 participants with a follow-up <1 month were selected to assess the intrasubject variability of the brain volume measurement. A mixed model evaluated PBVC/y dependence on age, sex, and magnetic resonance imaging parameters (scan vendor and magnetic field strength). PBVC/y was associated with age (p < 0.001), with 60- to 70-year-old participants showing twice more volume decrease than participants aged 30-40 years. PBVC/y was also associated with magnetic field strength, with higher decreases when measured by 1.5T than 3T scanners (p < 0.001). The variability of PBVC/y normative percentiles was narrower as the interscan interval was longer (e.g., 80th normative percentile was 50% smaller for participants with 2-year than with 1-year follow-up). The use of these normative data, eased by the freely available calculator, might help in better discriminating pathological from physiological conditions in the clinical setting.

Keywords: Aging; Atrophy; Brain volume; MRI; Normative data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / pathology*
  • Atrophy
  • Brain / diagnostic imaging*
  • Brain / pathology*
  • Diffusion Magnetic Resonance Imaging
  • Female
  • Humans
  • Imaging, Three-Dimensional
  • Longevity*
  • Male
  • Middle Aged
  • Multicenter Studies as Topic
  • Organ Size
  • Retrospective Studies
  • Young Adult