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. 2019 Jul 2;55(54):7792-7795.
doi: 10.1039/c9cc02203a.

Development of 2-aminoisobutyric Acid (Aib)-rich Cell-Penetrating Foldamers for Efficient siRNA Delivery

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Development of 2-aminoisobutyric Acid (Aib)-rich Cell-Penetrating Foldamers for Efficient siRNA Delivery

Takashi Misawa et al. Chem Commun (Camb). .

Abstract

We have designed and synthesized a set of cell-penetrating foldamers (CPFs), Blocks 1-8, composed of the common amino acids Leu, Arg, and Gly, as well as the helicogenic amino acid 2-aminoisobutyric acid. The findings showed that Block 3 could deliver siRNA into cells without significant cytotoxicity. We also demonstrated that Block 3 could be applied to selectively kill the oncogene-driven cancer cells.

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