Association of Three Simple Insulin Resistance Indexes with Prehypertension in Normoglycemic Subjects

Metab Syndr Relat Disord. 2019 Sep;17(7):374-379. doi: 10.1089/met.2019.0029. Epub 2019 Jun 18.


Background: Insulin resistance (IR) is the common pathophysiology of prehypertension and prediabetes. Recognition of IR in one of the two disease states is critical for carrying out preventive strategies of another disease state. This study aimed to explore which simple IR indexes were significantly associated with prehypertension in subjects with normoglycemia. Methods: A total of 108,370 adults without elevated fasting plasma glucose and hypertension were included in this study. The three simple IR indexes [triglycerides to high-density lipoprotein cholesterol ratio, the product of fasting triglycerides and glucose, and metabolic score for IR (METS-IR)] were calculated. Partial correlation was used to analyze the correlation between the three indicators and blood pressure (BP) levels, and logistic regression analysis was used to explore their association with prehypertension. Results: Among the three indicators, only METS-IR had positive correlations with systolic and diastolic blood pressure levels. Furthermore, METS-IR was also significantly associated with prehypertension, irrespective of the categorization of waist circumference (WC). The odds ratios of the highest quartile were 2.223 (95% confidence interval [CI]: 2.044-2.417) in all subjects, 2.022 (95% CI: 1.501-2.725) in elevated WC subgroup, and 1.815 (95% CI: 1.620-2.034) in normal WC subgroup. Conclusions: METS-IR was associated with prehypertension in normoglycemic Chinese subjects, which bypasses the impact of WC and might be valuable for the management of prehypertension and the prevention of prediabetes in different ethnic groups.

Keywords: metabolic score for insulin resistance (METS-IR); normoglycemia; prehypertension; product of fasting triglycerides and glucose (TyG); triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C).

MeSH terms

  • Adult
  • Blood Glucose / metabolism*
  • Body Mass Index
  • Cholesterol, HDL / blood
  • Cross-Sectional Studies
  • Female
  • Health Status Indicators*
  • Humans
  • Insulin Resistance*
  • Male
  • Middle Aged
  • Prehypertension / complications
  • Prehypertension / epidemiology*
  • Prehypertension / metabolism
  • Risk Factors
  • Triglycerides / blood
  • Waist Circumference


  • Blood Glucose
  • Cholesterol, HDL
  • Triglycerides