Security profile of direct anticoagulants. Preferred use in atrial fibrillation

Abstract

A multidisciplinary panel of cardiologists, neurologists, internal medicine and specialists in hemostasis and thrombosis has elaborated this document showing recent scientific evidences supporting a better profile of direct oral anticoagulants (DOACs) versus vitaminK antagonists (VKA), as well as the indications of specific antidotes and hemostatic agents to reverse the anticoagulant effects of DOACs. The analysis reinforces the best profile of DOACs and its special benefit in patients with basal high hemorrhagic risk.

Keywords: Anticoagulantes orales de acción directa; Antidotes; Antídotos; Direct oral anticoagulants; Gastrointestinal bleeding; Hemorragia gastrointestinal; Hemorragia intracraneal; Intracranial hemorrhage.