Macrophages Fertilize the Soil to Promote Hematopoietic Cell Growth

Laura Bennett; Melanie Mumau; Nancy A Speck

doi:10.1016/j.immuni.2019.05.017

Macrophages Fertilize the Soil to Promote Hematopoietic Cell Growth

Immunity. 2019 Jun 18;50(6):1342-1344. doi: 10.1016/j.immuni.2019.05.017.

Authors

Laura Bennett¹, Melanie Mumau¹, Nancy A Speck²

Affiliations

¹ Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: nancyas@upenn.edu.

Abstract

Inflammatory signals support the birth of hematopoietic stem cells in zebrafish embryos, but their cellular source in mammals is not known. In this issue, Mariani et al. (2019) report that macrophages are a primary source of pro-inflammatory signals that promote blood cell formation in mammalian embryos.

Publication types

Comment

MeSH terms

Animals
Aorta
Hematopoiesis
Hematopoietic Stem Cell Transplantation*
Hematopoietic Stem Cells
Macrophages
Soil*
Zebrafish

Substances

Soil

Abstract

Publication types

MeSH terms

Substances

Grants and funding