Mitochondrial fission requires DRP1 but not dynamins

doi:10.1038/s41586-019-1296-y

Comment

. 2019 Jun;570(7761):E34-E42.

doi: 10.1038/s41586-019-1296-y. Epub 2019 Jun 19.

Mitochondrial fission requires DRP1 but not dynamins

Tiago Branco Fonseca^#^{1

2

3}, Ángela Sánchez-Guerrero^#^{1

2}, Ira Milosevic⁴, Nuno Raimundo⁵

Affiliations

¹ Institute of Cellular Biochemistry, University Medical Center Göttingen, Göttingen, Germany.
² European Neuroscience Institute Göttingen, A Joint Initiative of the University Medical Center Göttingen and the Max-Planck-Society, Göttingen, Germany.
³ Department of Biology, University of Padova, Padova, Italy.
⁴ European Neuroscience Institute Göttingen, A Joint Initiative of the University Medical Center Göttingen and the Max-Planck-Society, Göttingen, Germany. imilose@gwdg.de.
⁵ Institute of Cellular Biochemistry, University Medical Center Göttingen, Göttingen, Germany. nuno.raimundo@med.uni-goettingen.de.

^# Contributed equally.

PMID: 31217603
DOI: 10.1038/s41586-019-1296-y

Comment

Mitochondrial fission requires DRP1 but not dynamins

Tiago Branco Fonseca et al. Nature. 2019 Jun.

. 2019 Jun;570(7761):E34-E42.

doi: 10.1038/s41586-019-1296-y. Epub 2019 Jun 19.

Authors

Tiago Branco Fonseca^#^{1

2

3}, Ángela Sánchez-Guerrero^#^{1

2}, Ira Milosevic⁴, Nuno Raimundo⁵

Affiliations

¹ Institute of Cellular Biochemistry, University Medical Center Göttingen, Göttingen, Germany.
² European Neuroscience Institute Göttingen, A Joint Initiative of the University Medical Center Göttingen and the Max-Planck-Society, Göttingen, Germany.
³ Department of Biology, University of Padova, Padova, Italy.
⁴ European Neuroscience Institute Göttingen, A Joint Initiative of the University Medical Center Göttingen and the Max-Planck-Society, Göttingen, Germany. imilose@gwdg.de.
⁵ Institute of Cellular Biochemistry, University Medical Center Göttingen, Göttingen, Germany. nuno.raimundo@med.uni-goettingen.de.

^# Contributed equally.

PMID: 31217603
DOI: 10.1038/s41586-019-1296-y

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Comment on

Multiple dynamin family members collaborate to drive mitochondrial division.
Lee JE, Westrate LM, Wu H, Page C, Voeltz GK. Lee JE, et al. Nature. 2016 Dec 1;540(7631):139-143. doi: 10.1038/nature20555. Epub 2016 Oct 31. Nature. 2016. PMID: 27798601 Free PMC article.

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References

1. Bleazard, W. et al. The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Nat. Cell Biol. 1, 298–304 (1999). - DOI
1. Cereghetti, G. M. et al. Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc. Natl Acad. Sci. USA 105, 15803–15808 (2008). - DOI
1. Kalia, R. et al. Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature 558, 401–405 (2018). - DOI
1. Ji, W. K., Hatch, A. L., Merrill, R. A., Strack, S. & Higgs, H. N. Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites. eLife 4, e11553 (2015). - DOI
1. Lee, J. E., Westrate, L. M., Wu, H., Page, C. & Voeltz, G. K. Multiple dynamin family members collaborate to drive mitochondrial division. Nature 540, 139–143 (2016). - DOI

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[1] Bleazard, W. et al. The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Nat. Cell Biol. 1, 298–304 (1999). - DOI

[2] Bleazard, W. et al. The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Nat. Cell Biol. 1, 298–304 (1999). - DOI

[3] Cereghetti, G. M. et al. Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc. Natl Acad. Sci. USA 105, 15803–15808 (2008). - DOI

[4] Cereghetti, G. M. et al. Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc. Natl Acad. Sci. USA 105, 15803–15808 (2008). - DOI

[5] Kalia, R. et al. Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature 558, 401–405 (2018). - DOI

[6] Kalia, R. et al. Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature 558, 401–405 (2018). - DOI

[7] Ji, W. K., Hatch, A. L., Merrill, R. A., Strack, S. & Higgs, H. N. Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites. eLife 4, e11553 (2015). - DOI

[8] Ji, W. K., Hatch, A. L., Merrill, R. A., Strack, S. & Higgs, H. N. Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites. eLife 4, e11553 (2015). - DOI

[9] Lee, J. E., Westrate, L. M., Wu, H., Page, C. & Voeltz, G. K. Multiple dynamin family members collaborate to drive mitochondrial division. Nature 540, 139–143 (2016). - DOI

[10] Lee, J. E., Westrate, L. M., Wu, H., Page, C. & Voeltz, G. K. Multiple dynamin family members collaborate to drive mitochondrial division. Nature 540, 139–143 (2016). - DOI

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Mitochondrial fission requires DRP1 but not dynamins

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Mitochondrial fission requires DRP1 but not dynamins

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