Iodination of terminal alkynes using KI/CuSO4 - A facile method with potential for radio-iodination

Trevor Ferris; Laurence Carroll; Ronnie C Mease; Alan C Spivey; Eric O Aboagye

doi:10.1016/j.tetlet.2019.02.041

Iodination of terminal alkynes using KI/CuSO₄ - A facile method with potential for radio-iodination

Tetrahedron Lett. 2019 Mar 28;60(13):936-939. doi: 10.1016/j.tetlet.2019.02.041.

Authors

Trevor Ferris¹, Laurence Carroll^{1

2}, Ronnie C Mease², Alan C Spivey³, Eric O Aboagye¹

Affiliations

¹ Comprehensive Cancer Imaging Centre, Department of Surgery & Cancer, Hammersmith Campus, Imperial College, London W12 0NN, UK.
² Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
³ Department of Chemistry, Molecular Sciences Research Hub, 80 Wood Lane, White City Campus, Imperial College, London W12 0BZ, UK.

Abstract

Herein, we report an efficient new method for the iodination of terminal alkynes using stoichiometric KI and CuSO₄ in a mix of acetonitrile and acetate buffer that holds promise for further development into a method for radio-iodination.

Abstract

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