Background: To compare the Mindray BC-5180 and Sysmex XN-1000 instruments by analyzing the results of complete blood count in the external quality assessment in Shandong Province in 2018.
Methods: In the external quality assessment, 10 batches of quality control materials were issued throughout the year. The test items were WBC, RBC, Hb, PLT, and HCT. The laboratories using Mindray BC-5180 and Sysmex XN-1000 were screened, and the results were analyzed by t test, Passing-Bablok regression analysis, and Bland-Altman analysis.
Results: Thirty-six laboratories using Mindray BC-5180 instruments and thirty-six laboratories using Sysmex XN-1000 instruments were screened, and the average difference between the two instruments results is not significant (P > 0.05, t test). Passing-Bablok regression analysis showed that the 95% confidence interval of the regression equation interception of each test item included 0, and the 95% confidence interval of the slope contained 1, r > 0.98, which showed that the correlation is good. The Bland-Altman analysis showed that both instruments had more than 95% of the points within the 95% consistency limit (WBC97.2%, RBC95.6%, PLT97.2%, Hb96.7%, HCT97.5%). Within the consistency limit, the absolute value of the difference between the Mindray BC-5180 instrument and the Sysmex XN-1000 instrument is WBC 0.14%, RBC 0.26%, PLT 2.7%, and Hb 1.9%. HCT is 0.69%, and the difference is clinically acceptable.
Conclusion: It can be considered that the two instruments have good correlation and consistency, and the two instruments can replace each other.
Keywords: Bland-Altman; Mindray BC-5180; Passing-Bablok; Sysmex XN-1000; complete blood count; consistency.
© 2019 The Authors Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc.