Bedside and electro-oculographic analysis of abnormal ocular movements in spinocerebellar degenerations: effects of thyrotropin-releasing hormone

Neurology. 1988 Jan;38(1):110-4. doi: 10.1212/wnl.38.1.110.


We studied ocular movements in 130 patients with spinocerebellar degenerations. Patients had blurred vision (33.3%), diplopia (40.2%), oscillopsia (18.6%), ocular flutter (22.3%), rebound nystagmus (25.4%), square-wave jerks, (29.2%), macro square-wave jerks (6.2%), and macro saccadic oscillations (10.8%). Electro-oculographic abnormalities included reduction of saccadic velocity, dysmetria, and saccadic smooth pursuit. All the abnormal movements were improved by the injection of thyrotropin-releasing hormone.

MeSH terms

  • Electrooculography
  • Eye Movements* / drug effects
  • Female
  • Humans
  • Male
  • Spinocerebellar Degenerations / drug therapy
  • Spinocerebellar Degenerations / physiopathology*
  • Thyrotropin-Releasing Hormone / therapeutic use*


  • Thyrotropin-Releasing Hormone