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Observational Study
, 24 (4), 260-265

Short- And Long-Term Effect of Contraceptive Methods on Fecundity

Observational Study

Short- And Long-Term Effect of Contraceptive Methods on Fecundity

Elina Berglund Scherwitzl et al. Eur J Contracept Reprod Health Care.


Objective: The aim of the study was to compare the effect of previously used contraceptive methods on women's short- and long-term fecundity. Use of hormonal contraception (HC) was compared with the use of a contraceptive mobile application (app). Methods: This real-life prospective observational study comprised 2874 women who were attempting to become pregnant using the Natural Cycles mobile app to monitor their fertility. The women registered to use the app between August 2014 and June 2016 with the intention of planning a pregnancy and had previously either used the same app to prevent pregnancy or had recently discontinued HC use. We calculated the average time to pregnancy (TTP) for all women who became pregnant during the study and performed Kaplan-Meier life-table analysis to examine the cumulative probabilities of pregnancy for all women in the study. Results: The average TTP was 2.3 (95% confidence interval [CI] 2.1, 2.4) and 3.7 (95% CI 3.4, 3.9) cycles for women who had previously used Natural Cycles and HC, respectively. The time to reach 30% pregnancy probability for women previously on HC was 1.6 (95% CI 1.5, 1.8) times longer than for women previously using Natural Cycles. There was no significant difference in the 13 cycle cumulated pregnancy probability between the two groups. Conclusion: The results show that fertility awareness-based methods of contraception increase short-term pregnancy rates relative to HC, but have no effect on long-term pregnancy rates.

Keywords: Conception rate; contraceptive; mobile application; subfertility; time to pregnancy.

Conflict of interest statement

Disclosure statement

EBS and RS are the scientists behind the Natural Cycles app and the founders of the company with stock ownership. OL and SPR is employed by NaturalCycles Nordic AB. KGD and HKK serve on the medical advisory board of NaturalCycles and have received honoraria for participating in advisory boards and/or giving presentations on matters related to contraception and fertility regulation for MSD/Merck, Bayer AG, Gedeon Richter, Exeltis, Actavis, Ferring (KGD), Exelgyn (KGD), HRA-Pharma (KGD) and Mithra (KGD). JH is on the medical advisory board of NaturalCycles, serves on the international advisory board of Finox, and has received honoraria for giving presentations related to infertility treatments in meetings arranged by MSD, Merck and Ferring. JT declares explicitly that there are no conflicts of interest in connection with this article.

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