Static perimetry in canthaxanthin maculopathy

Arch Ophthalmol. 1988 Jan;106(1):58-60. doi: 10.1001/archopht.1988.01060130064029.


We performed threshold static perimetry on 19 patients who had ingested canthaxanthin; 11 had maculopathy and eight did not. Patients with no history of canthaxanthin ingestion served as controls. All patients had visual acuity of 6/9 or better. Threshold static perimetry was reevaluated two to three years after cessation of canthaxanthin ingestion. For both testing sessions, patients with maculopathy presented lower retinal sensitivity than controls, while patients without maculopathy did not differ significantly from the control group. These results suggest that canthaxanthin retinopathy can adversely affect the neurosensory retina.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Canthaxanthin
  • Carotenoids / adverse effects
  • Carotenoids / analogs & derivatives*
  • Female
  • Humans
  • Macula Lutea*
  • Male
  • Middle Aged
  • Retina / pathology
  • Retinal Diseases / chemically induced*
  • Retinal Diseases / pathology
  • Retinal Diseases / physiopathology
  • Sensory Thresholds
  • Vision, Ocular
  • Visual Field Tests*


  • Carotenoids
  • Canthaxanthin