Review of polysaccharide particle-based functional drug delivery

Carbohydr Polym. 2019 Oct 1;221:94-112. doi: 10.1016/j.carbpol.2019.05.067. Epub 2019 May 26.

Abstract

This review investigates the significant role polysaccharide particles play in functional drug delivery. The importance of these systems is due to the wide variety of polysaccharides and their natural source meaning that they can provide biocompatible and biodegradable systems with a range of both biological and chemical functionality valuable for drug delivery. This functionality includes protection and presentation of working therapeutics through avoidance of the reticuloendothelial system, stabilization of biomacromolecules and increasing the bioavailability of incorporated small molecule drugs. Transport of the therapeutic is also key to the utility of polysaccharide particles, moving drugs from the site of administration through mucosal binding and transport and using chemistry, size and receptor mediated drug targeting to specific tissues. This review also scrutinizes the methods of synthesizing and constructing functional polysaccharide particle drug delivery systems that maintain and extend the functionality of the natural polysaccharides.

Keywords: Carbohydrate; Functional drug-delivery; Hydrogel; Polysaccharide.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Carriers / chemistry*
  • Drug Liberation
  • Humans
  • Polysaccharides / chemistry*

Substances

  • Drug Carriers
  • Polysaccharides