Anti-carcinogenic activity of d-limonene during the initiation and promotion/progression stages of DMBA-induced rat mammary carcinogenesis

Carcinogenesis. 1988 Feb;9(2):331-2. doi: 10.1093/carcin/9.2.331.


d-Limonene was found to be effective in reducing the average number of rat mammary carcinomas that developed in 7,12-dimethylbenz[a]anthracene-treated rats when the terpene was fed during the initiation or during the promotion/progression stage of carcinogenesis. The time to the appearance of the first tumor was extended only when d-limonene was fed during the initiation stage. These effects could not be attributed to changes in mammary-relevant endocrine functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene
  • Animals
  • Cocarcinogenesis*
  • Cyclohexenes
  • Diet
  • Female
  • Limonene
  • Mammary Neoplasms, Experimental / chemically induced
  • Mammary Neoplasms, Experimental / prevention & control*
  • Rats
  • Rats, Inbred Strains
  • Terpenes / pharmacology*


  • Cyclohexenes
  • Terpenes
  • 9,10-Dimethyl-1,2-benzanthracene
  • Limonene