Optic neuropathy from thiamine deficiency in a patient with ulcerative colitis

Doc Ophthalmol. 1987 Sep-Oct;67(1-2):45-51. doi: 10.1007/BF00142696.


A 35-year-old man with ulcerative colitis who was receiving parenteral feeding with large amounts of glucose, suddenly developed severe optic neuropathy and oculomotor palsy. The visual acuity fell bilaterally to 0. Although it was stated that thiamine has been regularly supplemented in the preceding period, high doses of vitamin B1 were given. Visual acuity promptly returned to 1.0 but large visual field defects persisted. Later on it appeared that erroneously no vitamin B1 has been given before.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Colitis, Ulcerative / complications*
  • Humans
  • Male
  • Medication Errors
  • Optic Nerve Diseases / etiology*
  • Optic Nerve Diseases / physiopathology
  • Papilledema / etiology
  • Papilledema / pathology
  • Parenteral Nutrition, Total
  • Retinal Hemorrhage / etiology
  • Retinal Hemorrhage / pathology
  • Thiamine / therapeutic use
  • Thiamine Deficiency / complications*
  • Visual Fields


  • Thiamine