A Novel, High-sensitivity, Bacteriophage-based Assay Identifies Low-level Mycobacterium tuberculosis Bacteremia in Immunocompetent Patients With Active and Incipient Tuberculosis

Clin Infect Dis. 2020 Feb 14;70(5):933-936. doi: 10.1093/cid/ciz548.

Abstract

The haematogenous dissemination of Mycobacterium tuberculosis (Mtb) is critical to the pathogenesis of progressive tuberculous infections in animal models. Using a novel, phage-based blood assay, we report the first concordant evidence in well-characterized, immunocompetent human cohorts, demonstrating associations of Mtb bacteremia with progressive phenotypes of latent infection and active pulmonary tuberculosis.

Keywords: bacteriophage; bacteremia; blood; human tuberculosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacteremia* / diagnosis
  • Bacteriophages*
  • Humans
  • Mycobacterium tuberculosis*
  • Tuberculosis*
  • Tuberculosis, Pulmonary* / diagnosis