Study of relationship between total vitamin D level and NAFLD in a sample of Egyptian patients with and without T2DM

Diabetes Metab Syndr. May-Jun 2019;13(3):1769-1771. doi: 10.1016/j.dsx.2019.04.002. Epub 2019 Apr 3.

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is increasing recently due to increasing the prevalence of obesity. Insulin resistance (IR) is the mutual pathological cause for both T2DM and NAFLD. Vitamin D acts against IR by its anti-inflammatory and regulation of insulin secretion as pancreatic beta cells express vitamin D receptor (VDR).

Aim: Assessment of relationship between Total vitamin D level and NAFLD a sample of Egyptian patients with and without T2DM.

Methods: The current study included 110 Egyptian subjects. They divided into 4 groups: Group 1: 30 diabetic patients with NAFLD Group 2: 30 diabetic patients without NAFLD Group 3: 30 NAFLD patients without diabetes Group 4: 20 healthy controls. Vitamin D level assessment, AST, ALT, GGT, total cholesterol, LDL, triglycerides, fasting and 2 h post prandial plasma glucose, glycosylated hemoglobin, albumin and creatinine calculation of FLI were assessed.

Result: There was a statistical significant decrease in total vitamin D level in T2DM patients with NAFLD than either T2DM or NAFLD only patients.(15.5 ± 7.46 vs 24.4 ± 8.19 and 22.86 ± 9.58 ng/ml respectively) also Total vitamin D level is negatively correlated with age, weight, BMI, WC, total cholesterol, LDL, TG, FPG, HbA1c and FLI.

Conclusion: There is a decrease in total vitamin D in T2DM patients with NAFLD.

Keywords: T2DM and NAFLD; Total vitamin D.

Publication types

  • Review

MeSH terms

  • Diabetes Mellitus, Type 2 / complications*
  • Humans
  • Insulin Resistance
  • Non-alcoholic Fatty Liver Disease / blood
  • Non-alcoholic Fatty Liver Disease / etiology*
  • Non-alcoholic Fatty Liver Disease / pathology
  • Vitamin D / blood*
  • Vitamin D Deficiency / physiopathology*
  • Vitamins / blood

Substances

  • Vitamins
  • Vitamin D