Vitamin D status in diabetic patients (type 2) and its relation to glycemic control & diabetic nephropathy

Diabetes Metab Syndr. 2019 May-Jun;13(3):1971-1973. doi: 10.1016/j.dsx.2019.04.040. Epub 2019 Apr 23.


Background: Vitamin D deficiency appears to be lower in diabetic patients. Vitamin D may affect glycemic control & diabetic nephropathy.

Aim: To assess vitamin D level in type 2 diabetic patients and its relation to their glycemic control and development of nephropathy compared to healthy controls.

Design: and Setting: Case control study including 82 participants (41 cases and 41 controls) from Family Medicine Clinic, Cairo University Hospitals.

Method: Participants fulfilling the inclusion criteria were allocated into two groups, diabetes and control groups. History was taken, examination was done, and blood sample was withdrawn for analysis of Vitamin D levels and HBA1C. From the diabetic group only, serum creatinine was assessed and urine sample was collected for microalbuminuria. The results were analyzed using SPSS program version 21.

Results: Vitamin D level was lower in the diabetic group compared to control (65.5% and 56.1%). Vitamin D level was inversely proportionate to HbA1c levels in the diabetic patients (p value 0.000 & r -0.482), as well as to the A/C ratio (p value 0.01 & r -0.396).

Conclusion: Vitamin D level appeared to be lower in diabetic patients and is associated with poor glycemic control & microalbuminuria.

Keywords: Diabetes mellitus; Diabetic nephropathy; Vitamin D.

MeSH terms

  • Adult
  • Biomarkers / analysis*
  • Blood Glucose / analysis
  • Case-Control Studies
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetic Nephropathies / etiology*
  • Diabetic Nephropathies / metabolism
  • Diabetic Nephropathies / pathology
  • Female
  • Follow-Up Studies
  • Glucose Intolerance / etiology*
  • Glucose Intolerance / metabolism
  • Glucose Intolerance / pathology
  • Glycated Hemoglobin / analysis
  • Glycemic Index
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Vitamin D / blood*
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / physiopathology*
  • Vitamins / blood


  • Biomarkers
  • Blood Glucose
  • Glycated Hemoglobin A
  • Vitamins
  • hemoglobin A1c protein, human
  • Vitamin D