Topical calcipotriol vs narrowband ultraviolet B in treatment of alopecia areata: a randomized-controlled trial

Arch Dermatol Res. 2019 Oct;311(8):629-636. doi: 10.1007/s00403-019-01943-8. Epub 2019 Jun 24.


Alopecia areata is a chronic relapsing autoimmune inflammatory hair disorder with no novel therapy. The objectives of this study are to compare the efficacy of topical calcipotriol vs narrow band ultraviolet B phototherapy (NB-UVB) in the treatment of alopecia areata and its correlation with serum vitamin D3 levels. A randomized-controlled trial has been conducted on 60 patients with scalp alopecia areata randomized into four groups; topical calcipotriol, NB-UVB, both and placebo. All patients were evaluated by assessment of severity of alopecia areata by severity of alopecia tool (SALT) score at baseline and 3 months after treatment and vitamin D3 levels at baseline and after 3 months. SALT score and vitamin D3 levels were significantly improved in all groups except placebo after treatment with (P = 0.026, P = 0.005, P = 0.004, P = 0.140) and (P = 0.028, P = 0.011, P = 0.003, P = 0.725), respectively. Combined therapy showed non-significant improvement in SALT score (P = 0.530, P = 0.643), respectively, and significant improvement in serum vitamin D3 levels than each line alone with (P = 0.021, P = 0.044), respectively. Both topical calcipotriol and NB-UVB are effective therapies in the treatment of AA and associated with improvement of SALT score and vitamin D3 levels.

Keywords: Alopecia areata; Calcipotriol; NB-UVB; Vitamin D3.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Alopecia Areata / blood
  • Alopecia Areata / diagnosis
  • Alopecia Areata / therapy*
  • Calcitriol / administration & dosage
  • Calcitriol / analogs & derivatives*
  • Cholecalciferol / blood
  • Combined Modality Therapy / methods
  • Dermatologic Agents / administration & dosage*
  • Female
  • Humans
  • Male
  • Severity of Illness Index
  • Treatment Outcome
  • Ultraviolet Therapy / methods*
  • Young Adult


  • Dermatologic Agents
  • calcipotriene
  • Cholecalciferol
  • Calcitriol