Hydrogels are interesting as wound dressing for burn wounds to maintain a moist environment. Especially gelatin and alginate based wound dressings show strong potential. Both polymers are modified by introducing photocrosslinkable functionalities and combined to hydrogel films (gel-MA/alg-MA). In one protocol gel-MA films are incubated in alg-MA solutions and crosslinked afterward into double networks. Another protocol involves blending both and subsequent photocrosslinking. The introduction of alginate into the gelatin matrix results in phase separation with polysaccharide microdomains in a protein matrix. Addition of alg(-MA) to gel-MA leads to an increased swelling compared to 100% gelatin and similar to the commercial Aquacel Ag dressing. In vitro tests show better cell adhesion for films which have a lower alginate content and also have superior mechanical properties. The hydrogel dressings exhibit good biocompatibility with adaptable cell attachment properties. An adequate gelatin-alginate ratio should allow application of the materials as wound dressings for several days without tissue ingrowth.
Keywords: alginate; burn wound; gelatin; hydrogels; wound dressing.
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Evaluation of an in Situ Forming Hydrogel Wound Dressing Based on Oxidized Alginate and GelatinB Balakrishnan et al. Biomaterials 26 (32), 6335-42. PMID 15919113.Wound dressings that can be formed in situ offer several advantages over the use of preformed dressings such as conformability without wrinkling or fluting in the wound b …
Evaluation of Fibroblasts Adhesion and Proliferation on Alginate-Gelatin Crosslinked HydrogelB Sarker et al. PLoS One 9 (9), e107952. PMID 25268892.Due to the relatively poor cell-material interaction of alginate hydrogel, alginate-gelatin crosslinked (ADA-GEL) hydrogel was synthesized through covalent crosslinking o …
Enzymatically Gellable Gelatin Improves Nano-Hydroxyapatite-Alginate Microcapsule Characteristics for Modular Bone Tissue FormationN Firouzi et al. J Biomed Mater Res A 108 (2), 340-350. PMID 31618526.To maintain gelatin (Gel) as adhesive motifs inside alginate microcapsule as building blocks of modular approach, phenol moiety (Ph) was introduced into gelatin (Gel Ph). …
Alginate in Wound DressingsBA Aderibigbe et al. Pharmaceutics 10 (2). PMID 29614804. - ReviewAlginate is a biopolymer used in a variety of biomedical applications due to its favourable properties, such as biocompatibility and non-toxicity. It has been particularl …
[Application Status and Research Progess of Alginate Dressings]Q Gu et al. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 28 (2), 255-8. PMID 24796205. - ReviewAlginate dressing, as an advanced bio-dressing, whose effectiveness has been confirmed, its derivative dressings are also continuously expanding.